Radiation Oncology

Radiation Biology Research Laboratory (page 3)

IV. Publications
A. Translational Research
Zhi-Min Yuan, M.D., Ph.D.

1) Yuan ZM, Fenselau C, Dulic DM, Martin W, Emary WB, Brundrett RB, Colvin M, Cotter RJ. Laser desorption electron impact: Application to a study of the mechanism of conjugation of glutathione of cyclophosphamide Anal.Chem.1990;62;868-870.

2) Yuan ZM, Smith PB, Brundrett RB, Colvin M, Fenselau C. Glutathione conjugation with phosphoramide mustard and cyclophosphamide. A mechanistic study using tandem mass spectrometry.Drug Metabolism and Disposition: The Biological Fate of Chemicals 1991;19:625-9.

3) Yuan ZM, Egorin MJ, Rosen DM, Callery, PS. Cytotoxic monoaziridinyl spermidines.Biochem Pharm. 1994;47:1587

4) Yuan ZM, Egorin MJ, Rosen MD, Simon MA, Callery PS. Cellular pharmacology of Aziridinyl analogues of permidine. Cancer Res. 1994;54:742-8.

5) Kharbanda S, Saleem A, Datta R, Yuan ZM, Weichselbaum R, Kufe D. Ionizing radiation induces rapid tyrosine phosphorylation of p34 cdc2. Cancer Res. 1994;54:412-4.

6) Kharbanda S, Yuan ZM, Rubin E, Welchselbaum R, Kufe D. Activation of the src-like p56/p53 Lyn tyrosine kinase by ionizing radiation. J. Biol. Chem. 1994; 269:20739-43.

7) Saleem A, Kharbanda S, Yuan ZM, Kufe D. Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-Kinase to Grb2-Sos complexes in human monocytes. J Biol. Chem. 1995;270:10380-3.

8) Saleem A, Yuan ZM, Taneja N, Rubin E, Kufe D, Kharbanda S. Activation of serine/threonine protein kinases and early response gene expression by TNF in human myeloid leukemia cells. J. Immunol. 1995;154:4150-6.

9) Yuan ZM, Kharbanda S, Kufe D. Arabinofuranosylcytosine activates tyrosine phosphorylation of p34 cdc2 and its association with the src-like p56/p53 Lyn kinases in human myeloid leukemia cells. Biochemistry 1995;34:1058-63.

10) Kharbanda S, Saleem A, Yuan ZM. Emoto Y, Prasad K, Kufe D. Stimulation of human monocytes with dynamin macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinases and Proc. Natl. Acad. Sci. USA 1995;92:6132-6.

11) Kharbanda S, Saleem A, Yuan ZM, Kraeft S, Weichselbaum R, Chen LB, Kufe D. Nuclear signaling induced by ionizing radiation involves colocalization of the activated p56/p53 lyn tyrosine kinase with p34cdc2. Cancer Res. 1996;5:3617-21.

12) Yuan ZM, Huang YY, Whang Y, Sawyers C, Weichselbaum R, Kufe D. Role of c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 1996;38:272-4.

13) Yuan ZM, Huang YY, Kraeft SK, Chen LB, Kufe D. Interaction of cyclin-dependent kinase 2 and the Lyn tyrosine kinase in cells treated with ara-C. Oncogene 1996;1:939-46.

14) Yuan ZM, Huang YY, Fan MM, Sawyers C, Kharbanda S, Kufe D. Cytotoxic drugs induce the association of c-Abl tyrosine kinase and tumor supressor p53. J. Biol. Chem. 1996;27:26457-60.

15) Yuan ZM, Huang YY, Weichselbaum R, Kufe, D. Regulation of DNA-damage induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl. Acad. Sci. USA 1997;94:1437-40.

16) Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, Weichselbaum R, Weaver D, Kufe D. Functional interaction between DNA-PK and c-Abl in the response to DNA damage. Nature 1997;386:732-5.

17) Yuan ZM, Utsugisawa T, Huang YY, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D. Inhibition of PI3-kinase by c-Abl in the genotoxic response. J. Biol. Chem. 1997;272:23485-8.

18) Huang YY, Yuan ZM, Ishiko T, Nakada S, Utsugisawa T, Kato T, Kharbanda S, Kufe D. Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to ara-C. Oncogene 1997;15:1947-52.

19) Huang YY, Ishiko T, Nakada S, Kato T, and Yuan ZM. Role for E2F in DNA damage-induced entry of cells into S phase. Cancer Res. 1997;57:3640-3.

20) Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Functional role for the c-Abl protein kinase in the cellular response to genotoxic stress. Biochemica et Biophysica Acta. 1997;1333:1-7.

21) Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang YY, Kharbanda S, Weichselbaum R, Kufe D. Activation of Protein kinase C delta by the c-Abl tyrosine kinase in response to genotoxic stress. Oncogene 1998;16:1643-1648.

22) Yuan ZM, Huang YY, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, Wang R, Sung P, Shinohara A, Weichselbaum R,Kufe D.Regulation of Rad51 function by c-Abl in the response to DNA damage.J.Biol. Chem. 1998;273:3799-802.

23) Yuan ZM, Huang YY, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y, Kufe D, Role of p300 in stabilization of p53 in the response to DNA damage. J. Biol. Chem. 1999 274(4):1883-6.

24) Huang Y, Nakada S, Ishiko T, Utsugisawa T, Datta R, Kharbanda S, Yoshida K, Talanian RV, Weichselbaum R, Kufe D, Yuan ZM. Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage.Mol Cell Biol. 199919(4):2986-97.

25) Yuan Z-M, Huang YY, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Shi Y,. Weichselbaum R, Kufe D. Function for p300 but not CBP in the apoptotic response to DNA damage. Oncogene. 1999 Oct 7;18(41):5714-7.

26) Yuan ZM, Shioya H, Ishiko T, Sun X, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D. p73 is regulation by the c-Abl tyrosine kinase in the apoptotic response to DNA damage. Nature 1999: 399(6738):814-7.

27) Gu J, Chen D, Rosenblum J, Rubin RM, Yuan ZM. Identification of a sequence element from p53 that signals for Mdm2-targeted degradation. Mol Cell Biol. 2000 20(4):1243-53.

28) Zeng X, Li X, Miller A, Yuan ZM, Yuan W, Kwok RP, Goodman R, Lu H. The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. Mol Cell Biol 2000 Feb;20(4):1299-310

29) Gu J, Rachel M. Rubin & Yuan ZM. The sequence element of p53 that signals for Mdm2-mediated Degradation is also required for HPV16 E6 and E1B 55k/E4 34k to target p53 for degradation. Oncogene, 2001 20:3519-27.

30) Gu J, Hidehiko Kawai, Dmitri Wiederschain, Jennifer M Varley & Yuan ZM. Mechanism of the functional inactivation in a Li-Fraumeni Syndrome p53 that has a mutation outside of the DNA binding domain..Cancer Res.2001 61: 1741-1746.

31) Wiederschain D, Gu J, Yuan ZM. Evidence for a Distinct Inhibitory Factor in the Regulation of p53 Functional Activity. J Biol Chem 2001 Jul 27;276(30):27999-8005.

32) Gu J, Nie L, Kawai H, Yuan ZM. Subcellular distribution of p53 and p73 are differentially regulated by MDM2. Cancer Res. 61: 6703-6707, 2001.

33) Kawai H, Nie L, Wiederschain D, Yuan ZM. Dual role of p300 in the regulation of p53 stability. J Biol Chem. 2001 276:45928-32.

34) Gu J, Nie L, Wiederschain D, Yuan ZM. Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. Mol Cell Biol 2001 21(24):8533-46.

35) Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem 2002 31;277(22):19251-4

36) Kawai H, Nie L, Yuan ZM. Inactivation of the NF?B-dependent cell survival, a novel mechanism for the pro-apoptotic function of c-Abl. Mol Cell Biol 2002 22.

37) Kitao H, Yuan ZM Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. J Biol Chem 277(50):48944-8, 2002.

38) Tsai KC & Yuan ZM. c-Abl stabilizes p73 by a phosphorylation-augmented interaction. Cancer Res 2003,15;63(12):3418-24.

39) Kawai H, Wiederschain D, Yuan ZM. Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Mol Cell Biol. 2003 Jul;23(14):4939-47.

40) Wiederschain D, Kawai H, Gu J, Shilatifard A, Yuan ZM. Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol. 2003 Jun;23(12):4230-46.

41) Kawai H, Wiederschain D, Kitao H, Stuart J, Tsai KK, Yuan ZM. DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem. 2003 278(46):45946-53.

42) Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004 Jan;36(1):55-62.

43) Toyoshima M, Shimura T, Adiga SK, Taga M, Shiraishi K, Inoue M, Yuan ZM, Niwa O. Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes. Oncogene. 2005 24(20):3229-35;

44) Wiederschain D, Kawai H, Shilatifard A, Yuan ZM. Multiple MLL fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem. 2005 Apr 25;

45) Tsai KK, Chuang EY, Little JB, Yuan ZM. Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res, 65(15): 6734-44, 2005

46) Wiederschain D, Kawai H, Shilatifard A, Yuan ZM Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem, 280(26): 24315-21, 2005.

47) Stuart JR, Kawai H, Tsai KK, Yuan ZM. c-Abl regulates Early Growth Response Protein (EGR1) in response to oxidative stress. Oncogene, 24(55): 8085-92, 2005.

48) Stuart JR, Gonzalez FH, Kawai H, Yuan ZM. C-ABL interacts with the wave2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem. 2006 281(42):31290-7;

49) Kim MM, Wiederschain D, Kennedy D, Hansen E, Yuan ZM Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). Oncogene. 2007 Jun 21;26(29):4209-15.

50) Hidehiko Kawai, Vanessa Lopez-Pajares, Mihee M. Kim, Dmitri Wiederschain and Yuan ZM. A requirement of RING domain-mediated interaction for MDM2’s E3 ligase activity. Cancer Research 2007, Jul 1;67(13):6026-30.

51) Lopez-Pajares V, Kim MM, Yuan ZM. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J Biol Chem. 2008 Mar 20;

52) Huang Y, Zhang J, Kim MM, McHenry M, Lopez- Pajares V, Zeng W, Dibble C, Mizgerd J, Yuan ZM. Induction of cytoplasm accumulation of p53, a mechanism for low levels of arsenic exposure to predispose cells to malignant transformation. Cancer Research 2008 Nov 15;68(22):9131-6.

53) Cai X and Yuan ZM. Stochastic Simulation of the p53-MDM2/MDMX Loop. Journal of Computational Biology. In press, 2009.

54) Tsai KC, Stuart J, Chuang YY, Little JB and Yuan ZM. Low Dose Radiation-induced Senescent Stromal Fibroblasts Render Nearby Breast Cancer Cells Radio-resistant. Radiation Research 174:in press, 2009.

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